NRAP May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix. Expressed in cardiac and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 19 D2|19 51.8 cM
Cellular Component:  fascia adherens; muscle tendon junction; myofibril; Z disc
Molecular Function:  actin binding; actin filament binding; metal ion binding; muscle alpha-actinin binding; protein binding; vinculin binding
Biological Process:  actin cytoskeleton organization; cardiac muscle thin filament assembly; muscle fiber development
Reference #:  Q80XB4 (UniProtKB)
Alt. Names/Synonyms: N-RAP; nebulin-related anchoring protein; Nebulin-related-anchoring protein; Nrap
Gene Symbols: Nrap
Molecular weight: 195,756 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene