XDH Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Belongs to the xanthine dehydrogenase family. Detected in milk (at protein level). Note: This description may include information from UniProtKB.
Protein type: EC; EC; Nucleotide Metabolism - purine; Oxidoreductase; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: 2p23.1
Cellular Component:  cytosol; peroxisome; sarcoplasmic reticulum
Molecular Function:  2 iron, 2 sulfur cluster binding; electron transfer activity; FAD binding; flavin adenine dinucleotide binding; iron ion binding; molybdopterin cofactor binding; protein homodimerization activity; xanthine dehydrogenase activity; xanthine oxidase activity
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; electron transport chain; lactation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; negative regulation of gene expression; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of vascular endothelial growth factor signaling pathway; negative regulation of vasculogenesis; positive regulation of p38MAPK cascade; positive regulation of reactive oxygen species metabolic process; purine nucleotide catabolic process; xanthine catabolic process
Disease: Xanthinuria, Type I
Reference #:  P47989 (UniProtKB)
Alt. Names/Synonyms: xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase; Xanthine oxidase; Xanthine oxidoreductase; XD; XDH; XDHA; XO; XOR
Gene Symbols: XDH
Molecular weight: 146,424 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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