|
XDH
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Belongs to the xanthine dehydrogenase family. Detected in milk (at protein level). Note: This description may include information from UniProtKB.
|
| Protein type: EC 1.17.1.4; EC 1.17.3.2; Nucleotide Metabolism - purine; Oxidoreductase; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes |
| Chromosomal Location of human Ortholog: 2p23.1 |
|
Cellular Component:
cytosol; extracellular space; peroxisome; sarcoplasmic reticulum
|
|
Molecular Function:
2 iron, 2 sulfur cluster binding; FAD binding; flavin adenine dinucleotide binding; hypoxanthine dehydrogenase activity; hypoxanthine oxidase activity; iron ion binding; molybdopterin cofactor binding; protein binding; protein homodimerization activity; xanthine dehydrogenase activity; xanthine oxidase activity
|
|
Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; adenosine catabolic process; allantoin metabolic process; amide catabolic process; AMP catabolic process; dAMP catabolic process; deoxyadenosine catabolic process; deoxyguanosine catabolic process; deoxyinosine catabolic process; dGMP catabolic process; GMP catabolic process; guanine catabolic process; hypoxanthine catabolic process; IMP catabolic process; inosine catabolic process; iron-sulfur cluster assembly; lactation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; negative regulation of gene expression; negative regulation of protein kinase B signaling; negative regulation of protein phosphorylation; negative regulation of vascular endothelial growth factor signaling pathway; negative regulation of vasculogenesis; positive regulation of p38MAPK cascade; positive regulation of reactive oxygen species metabolic process; xanthine catabolic process
|
|
Disease: Xanthinuria, Type I
|
|
Reference #:
P47989
(UniProtKB)
|
|
Alt. Names/Synonyms: XAN1; xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase; Xanthine oxidase; Xanthine oxidoreductase; XD; XDH; XDHA; XO; XOR
|
|
Gene Symbols: XDH
|
|
Molecular weight:
146,424 Da
|
|
Basal Isoelectric point:
7.86
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
