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NDEL1
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Belongs to the nudE family. Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Protease |
| Chromosomal Location of human Ortholog: 17p13.1 |
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Cellular Component:
axon cytoplasm; axon hillock; cell leading edge; centrosome; cytosol; kinesin complex; kinetochore; microtubule; neurofilament cytoskeleton; spindle; synaptic vesicle
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Molecular Function:
alpha-tubulin binding; beta-tubulin binding; identical protein binding; microtubule binding; protein binding
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Biological Process:
activation of GTPase activity; cell migration; central nervous system neuron axonogenesis; centrosome localization; cerebral cortex radially oriented cell migration; chromosome segregation; establishment of chromosome localization; establishment of mitotic spindle orientation; inner cell mass cell proliferation; insulin receptor signaling pathway; lysosome localization; microtubule nucleation; mitotic centrosome separation; neurofilament cytoskeleton organization; neuron projection extension; positive regulation of GTPase activity; positive regulation of ruffle assembly; radial glia-guided pyramidal neuron migration; regulation of intracellular protein transport; regulation of neuron projection development; retrograde axonal transport; vesicle transport along microtubule
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Reference #:
Q9GZM8
(UniProtKB)
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Alt. Names/Synonyms: DKFZp451M0318; endooligopeptidase A; EOPA; MITAP1; Mitosin-associated protein 1; mitosin-associated protein MITAP1; NDE1L1; NDE2; NDEL1; Nuclear distribution protein nudE-like 1; nudE neurodevelopment protein 1 like 1; nudE nuclear distribution E homolog-like 1; nudE nuclear distribution gene E homolog (A. nidulans)-like 1; nudE nuclear distribution gene E homolog like 1; nudE nuclear distribution gene E homolog-like 1; NUDE-like protein; NUDEL; Protein Nudel
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Gene Symbols: NDEL1
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Molecular weight:
38,375 Da
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Basal Isoelectric point:
5.16
Predict pI for various phosphorylation states
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