NDEL1 Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Protease
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component:  axon cytoplasm; axon hillock; cell leading edge; centrosome; condensed chromosome kinetochore; cytosol; kinesin complex; kinetochore; microtubule; neurofilament cytoskeleton; nuclear envelope; spindle; synaptic vesicle
Molecular Function:  alpha-tubulin binding; beta-tubulin binding; identical protein binding; microtubule binding; oligopeptidase activity; protein binding
Biological Process:  cell migration; central nervous system neuron axonogenesis; centrosome localization; cerebral cortex radially oriented cell migration; chromosome segregation; establishment of chromosome localization; establishment of mitotic spindle orientation; inner cell mass cell proliferation; insulin receptor signaling pathway; lysosome localization; microtubule nucleation; mitotic centrosome separation; neurofilament cytoskeleton organization and biogenesis; neuron migration; nuclear envelope disassembly; positive regulation of axon extension; positive regulation of axon regeneration; positive regulation of GTPase activity; positive regulation of ruffle assembly; proteolysis; regulation of intracellular protein transport; regulation of microtubule motor activity; regulation of neuron projection development; retrograde axon cargo transport; vesicle transport along microtubule
Reference #:  Q9GZM8 (UniProtKB)
Alt. Names/Synonyms: DKFZp451M0318; endooligopeptidase A; EOPA; MITAP1; Mitosin-associated protein 1; mitosin-associated protein MITAP1; NDEL1; Nuclear distribution protein nudE-like 1; nudE nuclear distribution gene E homolog (A. nidulans)-like 1; nudE nuclear distribution gene E homolog like 1; NUDE-like protein; NUDEL; Protein Nudel
Gene Symbols: NDEL1
Molecular weight: 38,375 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Select Structure to View Below

NDEL1

Protein Structure Not Found.


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