K6IRS3 Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. Belongs to the intermediate filament family. Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  cytosol; keratin filament
Molecular Function:  protein binding; structural molecule activity
Biological Process:  cornification; keratinization
Reference #:  Q86Y46 (UniProtKB)
Alt. Names/Synonyms: CK-73; Cytokeratin-73; IRT6IRS3; K2C73; K6IRS3; K73; KB36; keratin 6 irs3; keratin 73; Keratin, type II cytoskeletal 73; Keratin-73; KRT6IRS3; KRT73; MGC129635; MGC129636; Type II inner root sheath-specific keratin-K6irs3; Type-II keratin Kb36
Gene Symbols: KRT73
Molecular weight: 58,923 Da
Basal Isoelectric point: 6.93  Predict pI for various phosphorylation states
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K6IRS3

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene