ARHGAP21 Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of human Ortholog: 10p12.1|10p12.3
Cellular Component:  actin cytoskeleton; anchoring junction; cell junction; cytoplasmic vesicle membrane; cytosol; Golgi apparatus; Golgi membrane; plasma membrane
Molecular Function:  GTPase activator activity; protein binding
Biological Process:  establishment of Golgi localization; Golgi localization; Golgi organization; maintenance of Golgi location; organelle transport along microtubule; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  Q5T5U3 (UniProtKB)
Alt. Names/Synonyms: ARHGAP10; ARHGAP21; DKFZp761L0424; FLJ33323; FLJ90108; KIAA1424; RHG21; Rho GTPase activating protein 21; Rho GTPase-activating protein 10; Rho GTPase-activating protein 21; Rho-GTPase activating protein 10; Rho-type GTPase-activating protein 21
Gene Symbols: ARHGAP21
Molecular weight: 217,462 Da
Basal Isoelectric point: 7.85  Predict pI for various phosphorylation states
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ARHGAP21

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein