|
calpastatin
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Inhibitor |
| Chromosomal Location of mouse Ortholog: 13|13 C1 |
|
Cellular Component:
cytoplasm; cytosol; endoplasmic reticulum; membrane; postsynaptic density
|
|
Molecular Function:
calcium-dependent cysteine-type endopeptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity; peptidase inhibitor activity; protease binding
|
|
Biological Process:
egg activation; inhibition of cysteine-type endopeptidase activity; negative regulation of catalytic activity; negative regulation of peptidase activity; negative regulation of type B pancreatic cell apoptotic process; protein catabolic process
|
|
Reference #:
P51125
(UniProtKB)
|
|
Alt. Names/Synonyms: Calpain inhibitor; Calpastatin; calpastatin type III; Cast; ICAL
|
|
Gene Symbols: Cast
|
|
Molecular weight:
84,922 Da
|
|
Basal Isoelectric point:
5.37
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
