CXCR3 Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11. Belongs to the G-protein coupled receptor 1 family. Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component:  cytoplasm; integral component of plasma membrane; plasma membrane
Molecular Function:  C-X-C chemokine receptor activity; chemokine binding; chemokine receptor activity
Biological Process:  angiogenesis; apoptotic process; cell adhesion; cell surface receptor signaling pathway; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; regulation of cell adhesion; regulation of leukocyte migration; T cell chemotaxis
Reference #:  P49682 (UniProtKB)
Alt. Names/Synonyms: C-X-C chemokine receptor type 3; C-X-C motif chemokine receptor 3; CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C) receptor 3; chemokine receptor 3; CKR-L2; CMKAR3; CXC-R3; CXCR-3; CXCR3; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10 receptor; IP10-R; Mig receptor; Mig-R; MigR
Gene Symbols: CXCR3
Molecular weight: 40,660 Da
Basal Isoelectric point: 7.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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