POLE Participates in DNA repair and in chromosomal DNA replication. Belongs to the DNA polymerase type-B family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; DNA replication; EC; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase
Chromosomal Location of Human Ortholog: 5 F|5 53.45 cM
Cellular Component:  epsilon DNA polymerase complex; nucleoplasm; nucleus; plasma membrane
Molecular Function:  4 iron, 4 sulfur cluster binding; chromatin binding; DNA binding; DNA-directed DNA polymerase activity; iron-sulfur cluster binding; metal ion binding; nucleic acid binding; nucleotide binding; nucleotidyltransferase activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; transferase activity; zinc ion binding
Biological Process:  base-excision repair, gap-filling; cellular response to DNA damage stimulus; DNA biosynthetic process; DNA repair; DNA replication; DNA replication proofreading; DNA synthesis involved in DNA repair; G1/S transition of mitotic cell cycle; leading strand elongation; mitotic cell cycle; nucleotide-excision repair, DNA gap filling
Reference #:  Q9WVF7 (UniProtKB)
Alt. Names/Synonyms: 3'-5' exodeoxyribonuclease; DNA polymerase epsilon catalytic subunit A; DNA polymerase II subunit A; DNA-directed DNA polymerase epsilon; DPOE1; OTTMUSP00000032240; pol-epsilon; Pole; Pole1; polymerase (DNA directed), epsilon
Gene Symbols: Pole
Molecular weight: 262,100 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene