GABRA6 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of mouse Ortholog: 11 A5|11 25.03 cM
Cellular Component:  cell junction; cerebellar Golgi cell to granule cell synapse; chloride channel complex; dendrite; dendrite membrane; GABA-A receptor complex; GABA-ergic synapse; hippocampal mossy fiber to CA3 synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic specialization membrane; membrane; neuron projection; neuronal cell body membrane; plasma membrane; postsynapse; postsynaptic membrane; presynaptic membrane; receptor complex; synapse
Molecular Function:  chloride channel activity; drug binding; GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; ion channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  chemical synaptic transmission; chloride transmembrane transport; chloride transport; gamma-aminobutyric acid signaling pathway; ion transmembrane transport; ion transport; nervous system process; protein heterooligomerization; regulation of membrane potential; regulation of postsynaptic membrane potential; signal transduction; synaptic transmission, GABAergic
Reference #:  P16305 (UniProtKB)
Alt. Names/Synonyms: alpha6; GABA(A) receptor subunit alpha-6; GABA-ARalpha6; GABAA receptor alpha 6 subunit; Gabr; Gabra-6; Gabra6; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6; gamma-aminobutyric acid A recptor, subunit alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6; GBRA6; OTTMUSP00000006689; subunit alpha 6 gamma-aminobutyric acid (GABA-A) receptor
Gene Symbols: Gabra6
Molecular weight: 51,106 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene