GNL2 GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. Widely expressed, with the highest expression level in testis. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, misc.; Nucleolus
Chromosomal Location of Human Ortholog: 4|4 D2.2
Cellular Component:  nucleolus; nucleus
Molecular Function:  GTP binding; nucleotide binding
Biological Process:  ribosome biogenesis
Reference #:  Q99LH1 (UniProtKB)
Alt. Names/Synonyms: BC003262; Gnl2; guanine nucleotide binding protein-like 2 (nucleolar); HUMAUANTIG; MGC7863; Ngp-1; NOG2; Nucleolar GTP-binding protein 2; OTTMUSP00000009597; testicular antigen
Gene Symbols: Gnl2
Molecular weight: 83,345 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene