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GNL2
GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. Widely expressed, with the highest expression level in testis. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, misc.; Nucleolus |
| Chromosomal Location of human Ortholog: 1p34.3 |
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Cellular Component:
nucleolus; nucleus
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Molecular Function:
GTP binding; GTPase activity
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Biological Process:
ribosome biogenesis
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Reference #:
Q13823
(UniProtKB)
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Alt. Names/Synonyms: Autoantigen NGP-1; FLJ40906; G protein nucleolar 2; GNL2; guanine nucleotide binding protein-like 2 (nucleolar); HUMAUANTIG; Ngp-1; NGP1; NOG2; novel nucleolar guanosine 5'-triphosphate binding protein autoantigen; nucleolar G-protein gene 1; Nucleolar GTP-binding protein 2; nucleolar GTPase; nucleostemin-2; Nug2
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Gene Symbols: GNL2
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Molecular weight:
83,655 Da
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Basal Isoelectric point:
9.27
Predict pI for various phosphorylation states
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