ACTR8 Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. Belongs to the actin family. ARP8 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component:  centrosome; Ino80 complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; protein binding
Biological Process:  cell cycle; cell division; chromatin remodeling; DNA recombination; DNA repair; protein deubiquitination
Reference #:  Q9H981 (UniProtKB)
Alt. Names/Synonyms: Actin-related protein 8; ACTR8; ARP8; ARP8 actin-related protein 8 homolog (yeast); FLJ12934; FLJ22579; INO80 complex subunit N; INO80N
Gene Symbols: ACTR8
Molecular weight: 70,484 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
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ACTR8

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene