P2RY1 Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3|3 E1
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell body; cilium; dendrite; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of presynaptic active zone membrane; membrane; plasma membrane; postsynaptic density; postsynaptic membrane
Molecular Function:  A1 adenosine receptor binding; ADP binding; ADP-activated adenosine receptor activity; ATP binding; ATP-activated adenosine receptor activity; G protein-coupled purinergic nucleotide receptor activity; G protein-coupled receptor activity; nucleotide binding; protein heterodimerization activity; scaffold protein binding
Biological Process:  adenosine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cellular response to organic cyclic compound; cellular response to purine-containing compound; eating behavior; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway; glial cell migration; negative regulation of binding; negative regulation of norepinephrine secretion; phospholipase C-activating G protein-coupled receptor signaling pathway; platelet activation; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of hormone secretion; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of ion transport; positive regulation of penile erection; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; regulation of blood vessel diameter; regulation of cell shape; regulation of presynaptic cytosolic calcium ion concentration; regulation of signaling receptor activity; regulation of synaptic vesicle exocytosis; relaxation of muscle; response to mechanical stimulus; sensory perception of pain; signal transduction; signal transduction involved in regulation of gene expression
Reference #:  P49650 (UniProtKB)
Alt. Names/Synonyms: P2ry1; P2Y purinoceptor 1; P2Y1; P2Y1 receptor; purinergic receptor P2Y, G-protein coupled 1
Gene Symbols: P2ry1
Molecular weight: 42,213 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene