Moesin a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq12
Cellular Component:  apical part of cell; apical plasma membrane; basolateral plasma membrane; cell periphery; cell surface; cytoskeleton; cytosol; filopodium; invadopodium; microvillus; microvillus membrane; perinuclear region of cytoplasm; plasma membrane; pseudopodium; uropod
Molecular Function:  actin binding; cell adhesion molecule binding; double-stranded RNA binding; enzyme binding; protein binding; protein kinase binding; signaling receptor binding; structural constituent of cytoskeleton
Biological Process:  cellular response to testosterone stimulus; cytoskeleton organization; establishment of endothelial barrier; establishment of epithelial cell apical/basal polarity; gland morphogenesis; immunological synapse formation; interleukin-12-mediated signaling pathway; leukocyte cell-cell adhesion; leukocyte migration; membrane to membrane docking; positive regulation of cellular protein catabolic process; positive regulation of early endosome to late endosome transport; positive regulation of gene expression; positive regulation of podosome assembly; positive regulation of protein localization to early endosome; regulation of cell shape; regulation of cell size; regulation of lymphocyte migration; regulation of organelle assembly; T cell aggregation; T cell migration; T cell proliferation
Disease: Immunodeficiency 50
Reference #:  P26038 (UniProtKB)
Alt. Names/Synonyms: Membrane-organizing extension spike protein; MOES; Moesin; MSN
Gene Symbols: MSN
Molecular weight: 67,820 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Moesin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene