CDH6 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15|15 A1
Cellular Component:  catenin complex; cell surface; cell-cell adherens junction; integral component of membrane; membrane; plasma membrane
Molecular Function:  cadherin binding; calcium ion binding; cytoskeletal protein binding; metal ion binding; protein homodimerization activity
Biological Process:  adherens junction organization; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell morphogenesis; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell junction assembly; homophilic cell adhesion via plasma membrane adhesion molecules; Notch signaling pathway
Reference #:  P97326 (UniProtKB)
Alt. Names/Synonyms: cad6; CADH6; cadherin 6; Cadherin-6; Cdh6; K-cadherin; Kidney cadherin; MGC129338; MGC129360
Gene Symbols: Cdh6
Molecular weight: 88,355 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CDH6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein