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CCL28
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. Belongs to the intercrine beta (chemokine CC) family. Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 5p12 |
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Cellular Component:
extracellular region
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Molecular Function:
chemokine activity; protein binding
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Biological Process:
cell chemotaxis; chemotaxis; immune response; negative regulation of leukocyte tethering or rolling; positive regulation of cell-matrix adhesion; positive regulation of cytosolic calcium ion concentration; response to nutrient; signal transduction
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Reference #:
Q9NRJ3
(UniProtKB)
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Alt. Names/Synonyms: C-C motif chemokine 28; C-C motif chemokine ligand 28; CC chemokine CCL28; CCK1; CCL28; chemokine (C-C motif) ligand 28; chemokine (C-C motif) ligand 28 splice variant chi; MEC; MGC71902; Mucosae-associated epithelial chemokine; Protein CCK1; SCYA28; small inducible cytokine A28; small inducible cytokine subfamily A (Cys-Cys), member 28; Small-inducible cytokine A28
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Gene Symbols: CCL28
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Molecular weight:
14,280 Da
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Basal Isoelectric point:
10.23
Predict pI for various phosphorylation states
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