CCL28 Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. Belongs to the intercrine beta (chemokine CC) family. Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p12
Cellular Component:  cell; extracellular region
Molecular Function:  chemokine activity; protein binding
Biological Process:  cell chemotaxis; chemotaxis; G protein-coupled receptor signaling pathway; immune response; negative regulation of leukocyte tethering or rolling; positive regulation of cell-matrix adhesion; positive regulation of cytosolic calcium ion concentration; regulation of signaling receptor activity; response to nutrient
Reference #:  Q9NRJ3 (UniProtKB)
Alt. Names/Synonyms: C-C motif chemokine 28; CC chemokine CCL28; CCK1; CCL28; chemokine (C-C motif) ligand 28; MEC; MGC71902; Mucosae-associated epithelial chemokine; Protein CCK1; SCYA28; small inducible cytokine A28; small inducible cytokine subfamily A (Cys-Cys), member 28; Small-inducible cytokine A28
Gene Symbols: CCL28
Molecular weight: 14,280 Da
Basal Isoelectric point: 10.23  Predict pI for various phosphorylation states
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CCL28

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB