DYRK1A Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; DYRK1 subfamily; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of human Ortholog: 21q22.13
Cellular Component:  axon; cytoplasm; cytoskeleton; dendrite; nuclear speck; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  ATP binding; histone H3T45 kinase activity; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein self-association; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity; tau protein binding; tau-protein kinase activity; transcription coactivator activity
Biological Process:  amyloid-beta formation; chromatin remodeling; circadian rhythm; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of DNA methylation-dependent heterochromatin formation; negative regulation of microtubule polymerization; negative regulation of mRNA splicing, via spliceosome; nervous system development; peptidyl-serine autophosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of DNA-templated transcription; positive regulation of protein deacetylation; positive regulation of RNA splicing; protein autophosphorylation; protein phosphorylation; regulation of transcription by RNA polymerase II
Disease: Mental Retardation, Autosomal Dominant 7
Reference #:  Q13627 (UniProtKB)
Alt. Names/Synonyms: dual specificity tyrosine phosphorylation regulated kinase 1A; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; DYR1A; DYRK; DYRK1; DYRK1A; hMNB; HP86; MNB; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MRD7; Protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Gene Symbols: DYRK1A
Molecular weight: 85,584 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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