SCD Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays an important role in body energy homeostasis. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides. Belongs to the fatty acid desaturase type 1 family. Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.19.1; Endoplasmic reticulum; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase
Chromosomal Location of human Ortholog: 10q24.31
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; nucleolus
Molecular Function:  iron ion binding; oxidoreductase activity; protein binding; stearoyl-CoA 9-desaturase activity
Biological Process:  fatty-acyl-CoA biosynthetic process; oxidation-reduction process; positive regulation of cold-induced thermogenesis; regulation of cholesterol biosynthetic process; unsaturated fatty acid biosynthetic process
Reference #:  O00767 (UniProtKB)
Alt. Names/Synonyms: ACOD; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; delta-9-desaturase; FADS5; Fatty acid desaturase; hSCD1; MSTP008; predicted protein of HQ0998; SCD; SCD1; SCDOS; Stearoyl-CoA desaturase; stearoyl-CoA desaturase (delta-9-desaturase); stearoyl-CoA desaturase opposite strand
Gene Symbols: SCD
Molecular weight: 41,523 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SCD

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene