|
SCD
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays an important role in body energy homeostasis. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides. Belongs to the fatty acid desaturase type 1 family. Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung. Note: This description may include information from UniProtKB.
|
| Protein type: EC 1.14.19.1; Endoplasmic reticulum; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase |
| Chromosomal Location of human Ortholog: 10q24.31 |
|
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; membrane; nucleolus
|
|
Molecular Function:
iron ion binding; oxidoreductase activity; palmitoyl-CoA 9-desaturase activity; protein binding; stearoyl-CoA 9-desaturase activity
|
|
Biological Process:
monounsaturated fatty acid biosynthetic process; positive regulation of cold-induced thermogenesis; response to fatty acid; unsaturated fatty acid biosynthetic process
|
|
Reference #:
O00767
(UniProtKB)
|
|
Alt. Names/Synonyms: ACOD; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; delta-9-desaturase; FADS5; Fatty acid desaturase; hSCD1; MSTP008; predicted protein of HQ0998; SCD; SCD1; SCDOS; Stearoyl-CoA desaturase; stearoyl-CoA desaturase (delta-9-desaturase); stearoyl-CoA desaturase opposite strand
|
|
Gene Symbols: SCD
|
|
Molecular weight:
41,523 Da
|
|
Basal Isoelectric point:
9.07
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
