ATG4D Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability. Belongs to the peptidase C54 family. Mainly expressed in skeletal muscle and, to a lower extent, in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 9|9 A3
Cellular Component:  mitochondrion
Molecular Function:  cysteine-type peptidase activity; hydrolase activity; peptidase activity
Biological Process:  apoptotic process; protein transport; proteolysis
Reference #:  Q8BGV9 (UniProtKB)
Alt. Names/Synonyms: 9830134P12Rik; APG4 (ATG4) autophagy-related homolog D; APG4-D; Apg4d; Atg4d; Atg4dl; AUT-like 4 cysteine endopeptidase; AUT-like 4, cysteine endopeptidase; Autl4; Autophagin-4; autophagy-related 4D (yeast); autophagy-related 4D-like; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D; Cysteine protease ATG4D; cysteine protease involved in autophagy APG4-D; MGC31226
Gene Symbols: Atg4d
Molecular weight: 52,910 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene