ALDH18A1 Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC; EC; Kinase, other; Mitochondrial; Oxidoreductase
Chromosomal Location of mouse Ortholog: 19|19 C3
Cellular Component:  cytoplasm; cytosol; membrane; mitochondrial inner membrane; mitochondrial membrane; mitochondrion
Molecular Function:  ATP binding; catalytic activity; glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity; identical protein binding; kinase activity; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; transferase activity
Biological Process:  cellular amino acid biosynthetic process; citrulline biosynthetic process; glutamate metabolic process; metabolic process; ornithine biosynthetic process; oxidation-reduction process; phosphorylation; proline biosynthetic process; response to temperature stimulus
Reference #:  Q9Z110 (UniProtKB)
Alt. Names/Synonyms: 2810433K04Rik; AI429789; aldehyde dehydrogenase 18 family, member A1; Aldehyde dehydrogenase family 18 member A1; Aldh18a1; Delta-1-pyrroline-5-carboxylate synthase; delta-1-pyrroline-5-carboxylate synthetase; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GK; Glutamate 5-kinase; glutamate gamma-semialdehyde synthetase; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GPR; MGC32233; P5CS; Pycs; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
Gene Symbols: Aldh18a1
Molecular weight: 87,266 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene