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ALDH18A1
Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - arginine and proline; EC 1.2.1.41; EC 2.7.2.11; Kinase, other; Mitochondrial; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 19|19 C3 |
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Cellular Component:
cytoplasm; membrane; mitochondrial inner membrane; mitochondrial membrane; mitochondrion
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Molecular Function:
ATP binding; catalytic activity; glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity; identical protein binding; kinase activity; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; transferase activity
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Biological Process:
amino acid biosynthetic process; citrulline biosynthetic process; glutamate metabolic process; metabolic process; ornithine biosynthetic process; phosphorylation; proline biosynthetic process; response to temperature stimulus
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Reference #:
Q9Z110
(UniProtKB)
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Alt. Names/Synonyms: 2810433K04Rik; AI429789; aldehyde dehydrogenase 18 family, member A1; Aldehyde dehydrogenase family 18 member A1; Aldh18a1; Delta-1-pyrroline-5-carboxylate synthase; delta-1-pyrroline-5-carboxylate synthetase; Gamma-glutamyl kinase; Gamma-glutamyl phosphate reductase; GK; Glutamate 5-kinase; glutamate gamma-semialdehyde synthetase; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GPR; MGC32233; P5CS; Pycs; pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)
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Gene Symbols: Aldh18a1
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Molecular weight:
87,266 Da
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Basal Isoelectric point:
7.18
Predict pI for various phosphorylation states
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