SIGLEC7 Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7 B3|7
Cellular Component:  external side of plasma membrane; integral component of membrane; membrane
Molecular Function:  carbohydrate binding; monosaccharide binding; protein binding; sialic acid binding
Biological Process:  cell adhesion; negative regulation of inflammatory response; negative regulation of phagocytosis, engulfment
Reference #:  Q91Y57 (UniProtKB)
Alt. Names/Synonyms: Cd170; MIS; mSigle; mSiglec-E; Myeloid inhibitory siglec; sialic acid binding Ig-like lectin 5; sialic acid binding Ig-like lectin E; Sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin E; Sialic acid-binding Ig-like lectin-like 1; sialic acid-binding immunoglobulin-like lectin E; SIG12; Sigl; Siglec-12; Siglec-5; Siglec-E; Siglec-L1; SIGLEC-like 1; Siglec12; Siglec5; SIGLEC7; Siglec9; Siglece; Siglecl1
Gene Symbols: Siglec12
Molecular weight: 51,901 Da
Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene