GPR64 Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: X|X F4
Cellular Component:  apical plasma membrane; cytosol; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  G protein-coupled receptor activity; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; signal transduction
Reference #:  Q8CJ12 (UniProtKB)
Alt. Names/Synonyms: Adgrg2; adhesion G protein-coupled receptor G2; Adhesion G-protein coupled receptor G2; AGRG2; AW212196; B830041D06Rik; epididymis-specific protein 6; G protein coupled receptor He6; G protein-coupled receptor 64; G-protein coupled receptor 64; Gpr; Gpr64; LNB-TM7 heptahelical receptor Me6; Me6; Mouse epididymis-specific protein 6; OTTMUSP00000021149; OTTMUSP00000021152
Gene Symbols: Gpr64
Molecular weight: 110,200 Da
Basal Isoelectric point: 6.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene