MKK7 a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  ATP binding; enzyme binding; magnesium ion binding; MAP kinase kinase activity; protein binding; protein kinase binding; protein phosphatase binding; protein tyrosine kinase activity
Biological Process:  activation of JUN kinase activity; apoptotic process; Fc-epsilon receptor signaling pathway; JNK cascade; peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; positive regulation of transcription, DNA-templated; response to heat; response to osmotic stress; response to tumor necrosis factor; response to UV; signal transduction; stress-activated MAPK cascade
Reference #:  O14733 (UniProtKB)
Alt. Names/Synonyms: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; JNKK2; MAP kinase kinase 7; MAP2K7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MEK7; mitogen-activated protein kinase kinase 7; MKK7; MP2K7; PRKMK7
Gene Symbols: MAP2K7
Molecular weight: 47,485 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene