CHI3L1 Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. Belongs to the glycosyl hydrolase 18 family. Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  cytoplasm; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; perinuclear region of cytoplasm; specific granule lumen
Molecular Function:  carbohydrate binding; chitin binding; extracellular matrix structural constituent; protein binding
Biological Process:  activation of NF-kappaB-inducing kinase activity; apoptotic process; carbohydrate metabolic process; cartilage development; cellular response to interleukin-1; cellular response to tumor necrosis factor; inflammatory response; interleukin-8 secretion; lung development; neutrophil degranulation; positive regulation of angiogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of peptidyl-threonine phosphorylation; positive regulation of protein kinase B signaling; response to interleukin-1; response to interleukin-6; response to mechanical stimulus; response to tumor necrosis factor
Disease: Asthma-related Traits, Susceptibility To, 7; Schizophrenia
Reference #:  P36222 (UniProtKB)
Alt. Names/Synonyms: 39 kDa synovial protein; ASRT7; Cartilage glycoprotein 39; CGP-39; CH3L1; CHI3L1; chitinase 3 like 1; chitinase 3-like 1; chitinase 3-like 1 (cartilage glycoprotein-39); Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YKL-40; YKL40; YYL-40
Gene Symbols: CHI3L1
Molecular weight: 42,625 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHI3L1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene