ACOT12 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 12/ACOT12 preferentially hydrolyzes acetyl-CoA. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - pyruvate; EC 3.1.2.1; Hydrolase
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component:  cytosol
Molecular Function:  acetyl-CoA hydrolase activity; ATP binding; carboxylic ester hydrolase activity; lipid binding
Biological Process:  acetyl-CoA metabolic process; acyl-CoA metabolic process; pyruvate metabolic process
Reference #:  Q8WYK0 (UniProtKB)
Alt. Names/Synonyms: Acetyl-coenzyme A thioesterase; ACO12; ACOT12; Acyl-CoA thioester hydrolase 12; Acyl-CoA thioesterase 12; Acyl-coenzyme A thioesterase 12; CACH; CACH-1; CACH1; Cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase; hCACH-1; MGC105114; StAR-related lipid transfer (START) domain containing 15; STARD15; START domain-containing protein 15; THEAL
Gene Symbols: ACOT12
Molecular weight: 62,034 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
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ACOT12

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene