ACOT12
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 12/ACOT12 preferentially hydrolyzes acetyl-CoA. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Carbohydrate Metabolism - pyruvate; EC 3.1.2.1; Hydrolase |
Chromosomal Location of human Ortholog: 5q14.1 |
Cellular Component:
cytosol; intercellular bridge; nucleoplasm
|
Molecular Function:
acetyl-CoA hydrolase activity; acyl-CoA hydrolase activity; ATP binding; carboxylic ester hydrolase activity; identical protein binding; lipid binding; protein binding
|
Biological Process:
acetyl-CoA metabolic process; acyl-CoA metabolic process; fatty acid metabolic process
|
Reference #:
Q8WYK0
(UniProtKB)
|
Alt. Names/Synonyms: Acetyl-coenzyme A thioesterase; ACO12; ACOT12; Acyl-CoA thioester hydrolase 12; Acyl-CoA thioesterase 12; Acyl-coenzyme A thioesterase 12; CACH; CACH-1; CACH1; Cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase; hCACH-1; MGC105114; StAR-related lipid transfer (START) domain containing 15; STARD15; START domain-containing protein 15; THEAL
|
Gene Symbols: ACOT12
|
Molecular weight:
62,034 Da
|
Basal Isoelectric point:
6.3
Predict pI for various phosphorylation states
|