PARN 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability. Belongs to the CAF1 family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleolus; RNA-binding; Ribonuclease
Chromosomal Location of Human Ortholog: 16p13.12
Cellular Component:  cytosol; nucleolus; nucleus
Molecular Function:  cation binding; metal ion binding; mRNA 3'-UTR binding; nuclease activity; poly(A)-specific ribonuclease activity; protein binding; protein kinase binding; telomerase RNA binding
Biological Process:  box H/ACA snoRNA 3'-end processing; female gamete generation; miRNA catabolic process; ncRNA deadenylation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA poly(A) tail shortening; polyadenylation-dependent snoRNA 3'-end processing; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of mRNA stability; regulation of telomerase RNA localization to Cajal body; RNA modification; RNA phosphodiester bond hydrolysis, exonucleolytic; telomerase RNA stabilization
Disease: Dyskeratosis Congenita, Autosomal Recessive, 6; Pulmonary Fibrosis And/or Bone Marrow Failure, Telomere-related, 4
Reference #:  O95453 (UniProtKB)
Alt. Names/Synonyms: DAN; Deadenylating nuclease; Deadenylation nuclease; PARN; poly(A)-specific ribonuclease (deadenylation nuclease); Poly(A)-specific ribonuclease PARN; Polyadenylate-specific ribonuclease
Gene Symbols: PARN
Molecular weight: 73,451 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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