HCN3 Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. Belongs to the potassium channel HCN family. Detected in brain. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 3|3 F1
Cellular Component:  axon; cone cell pedicle; dendrite; integral component of membrane; integral component of plasma membrane; membrane; neuronal cell body; plasma membrane; synapse
Molecular Function:  cAMP binding; ion channel activity; nucleotide binding; potassium channel activity; protein binding; sodium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity
Biological Process:  ion transport; potassium ion transmembrane transport; potassium ion transport; regulation of ion transmembrane transport; regulation of membrane potential; sodium ion transmembrane transport; sodium ion transport; transmembrane transport
Reference #:  O88705 (UniProtKB)
Alt. Names/Synonyms: BCNG-4; Bcng4; Hac; HAC-3; Hac3; Hcn3; Hcn4; Hyperpolarization-activated cation channel 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; OTTMUSP00000030631; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Gene Symbols: Hcn3
Molecular weight: 86,641 Da
Basal Isoelectric point: 9.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene