ENTPD1 In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. Belongs to the GDA1/CD39 NTPase family. Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Extracellular matrix; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  8-oxo-dGTP phosphohydrolase activity; ATP binding; dATP phosphohydrolase activity; dCTP phosphohydrolase activity; dGTP phosphohydrolase activity; dTTP phosphohydrolase activity; dUTP phosphohydrolase activity; GTP phosphohydrolase activity; protein binding
Biological Process:  blood coagulation; cell adhesion; nucleobase-containing small molecule catabolic process
Disease: Spastic Paraplegia 64, Autosomal Recessive
Reference #:  P49961 (UniProtKB)
Alt. Names/Synonyms: ATPDase; CD39; CD39 antigen; DKFZp686D194; DKFZp686I093; Ecto-apyrase; Ecto-ATP diphosphohydrolase 1; Ecto-ATPase 1; Ecto-ATPDase 1; Ectonucleoside triphosphate diphosphohydrolase 1; ENTP1; ENTPD1; FLJ40921; FLJ40959; Lymphoid cell activation antigen; NTPDase 1; NTPDase-1; SPG64
Gene Symbols: ENTPD1
Molecular weight: 57,965 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein