AK7 Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function. In the C-terminal section; belongs to the dpy-30 family. Expressed in sperm and airway epithelial cells (at protein level). Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, other; Nucleotide Metabolism - purine
Chromosomal Location of human Ortholog: 14q32.2
Cellular Component:  cytosol; motile cilium
Molecular Function:  adenylate kinase activity; ATP binding; cytidylate kinase activity; nucleoside diphosphate kinase activity
Biological Process:  cell projection organization; nucleobase-containing small molecule interconversion; nucleoside diphosphate phosphorylation; nucleoside monophosphate phosphorylation; nucleoside triphosphate biosynthetic process
Disease: Spermatogenic Failure 27
Reference #:  Q96M32 (UniProtKB)
Alt. Names/Synonyms: Adenylate kinase 7; AK 7; AK7; ATP-AMP transphosphorylase 7; CFAP75; FAP75; FLJ32864; KAD7; Putative adenylate kinase 7; SPGF27
Gene Symbols: AK7
Molecular weight: 82,658 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB