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MMP2
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. Belongs to the peptidase M10A family. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Cell development/differentiation; EC 3.4.24.24; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 8 C5|8 44.99 cM |
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Cellular Component:
extracellular matrix; extracellular region; extracellular space; membrane; nucleus; plasma membrane; sarcomere
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Molecular Function:
endopeptidase activity; fibronectin binding; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; serine-type endopeptidase activity; zinc ion binding
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Biological Process:
angiogenesis; blood vessel maturation; bone trabecula formation; cell migration; cellular response to amino acid stimulus; cellular response to estradiol stimulus; cellular response to reactive oxygen species; cellular response to UV-A; collagen catabolic process; embryo implantation; extracellular matrix organization; face morphogenesis; heart development; intramembranous ossification; macrophage chemotaxis; negative regulation of cell adhesion; negative regulation of vasoconstriction; ovarian follicle development; peripheral nervous system axon regeneration; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell proliferation; prostate gland epithelium morphogenesis; protein catabolic process; proteolysis; response to amyloid-beta; response to estrogen; response to hydrogen peroxide; response to hypoxia; response to mechanical stimulus; response to oxidative stress; response to xenobiotic stimulus; skeletal system morphogenesis; tissue remodeling
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Reference #:
P33434
(UniProtKB)
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Alt. Names/Synonyms: 72 kDa gelatinase; 72 kDa type IV collagenase; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; Clg; Clg4a; GelA; Gelatinase A; matrix metallopeptidase 2; matrix metalloproteinase 2; Matrix metalloproteinase-2; MMP-; MMP-2; Mmp2; PEX
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Gene Symbols: Mmp2
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Molecular weight:
74,102 Da
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Basal Isoelectric point:
5.31
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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GPCR Signaling to MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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