ACP5 Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - riboflavin; EC; Motility/polarity/chemotaxis; Phosphatase
Chromosomal Location of mouse Ortholog: 9 A3|9 8.38 cM
Cellular Component:  extracellular space; lysosome
Molecular Function:  acid phosphatase activity; ferric iron binding; ferrous iron binding; hydrolase activity; metal ion binding
Biological Process:  bone morphogenesis; bone resorption; defense response to Gram-positive bacterium; dephosphorylation; interleukin-1 beta production; interleukin-12 production; macrophage cytokine production; negative regulation of cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-12 production; negative regulation of macrophage cytokine production; negative regulation of nitric oxide biosynthetic process; negative regulation of superoxide anion generation; negative regulation of tumor necrosis factor production; nitric oxide biosynthetic process; positive regulation of cell migration; response to cytokine; response to lipopolysaccharide; superoxide anion generation; tumor necrosis factor production
Reference #:  Q05117 (UniProtKB)
Alt. Names/Synonyms: acid phosphatase 5, tartrate resistant; acid phosphatase type V; Acp5; PPA5; T5ap; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR-AP; TRACP; Trap; TrATPase; Type 5 acid phosphatase
Gene Symbols: Acp5
Molecular weight: 36,807 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein