Henkels KM, et al. (2009) PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 389, 224-8 19715678

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y179-p - PLD2 (human) ▲

Modsite: RLLtMSFyRNYHAMT SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y179‑p, PLD2 (mouse): Y179‑p, PLD2 (rat): Y179‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Downstream Regulation Effect of modification (function):  enzymatic activity, induced, molecular association, regulation Effect of modification (process):  cell growth, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays GRB2 (human) Induces functional assay CD45 (human) Disrupts functional assay Comments:  dephosphorylated Y179 and Y511 mediates an induction of cell proliferation

Y296-p - PLD2 (human) ▲

Modsite: LILkCSSyRQARWWA SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y296‑p, PLD2 (mouse): Y296‑p, PLD2 (rat): Y296‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Downstream Regulation Effect of modification (function):  enzymatic activity, induced

Y415-p - PLD2 (human) ▲

Modsite: ALGINSGysKRALML SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y415‑p, PLD2 (mouse): Y415‑p, PLD2 (rat): Y415‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Downstream Regulation Effect of modification (function):  enzymatic activity, induced

Y511-p - PLD2 (human) ▲

Modsite: FFWLGKDySNLITKD SwissProt Entrez-Gene Orthologous residues PLD2 (human): Y511‑p, PLD2 (mouse): Y511‑p, PLD2 (rat): Y511‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  COS (fibroblast) Cellular systems studied:  cell lines Species studied:  green monkey Downstream Regulation Effect of modification (function):  enzymatic activity, induced, molecular association, regulation Effect of modification (process):  cell growth, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CD45 (human) Disrupts functional assay GRB2 (human) Induces functional assay Comments:  dephosphorylated Y179 and Y511 mediates an induction of cell proliferation