Curated Information
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Home > Curated Information Page > PubMed Id: 19725955
Ito T, et al. (2009) Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol 9, 47 19725955
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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R74-me - SOX9 (mouse)
Modsite: DKFPVCIrEAVSQVL SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): R74‑me, SOX9 (mouse): R74‑me, SOX9 (rat): R74‑me, SOX9 (chicken): R74‑me
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE CARM1 (mouse) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell cycle regulation, cell growth, induced, transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNB1 (human) Disrupts co-immunoprecipitation
Comments:  promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis

R152-me - SOX9 (mouse)
Modsite: LLNESEKrPFVEEAE SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): R152‑me, SOX9 (mouse): R152‑me, SOX9 (rat): R152‑me, SOX9 (chicken): R152‑me
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE CARM1 (mouse) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell cycle regulation, cell growth, induced, transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNB1 (human) Disrupts co-immunoprecipitation
Comments:  promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis

R177-me - SOX9 (mouse)
Modsite: PDYKYQPrrrKsVKN SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): R177‑me, SOX9 (mouse): R177‑me, SOX9 (rat): R177‑me, SOX9 (chicken): R177‑me
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE CARM1 (mouse) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell cycle regulation, cell growth, induced, transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNB1 (human) Disrupts co-immunoprecipitation
Comments:  promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis

R178-me - SOX9 (mouse)
Modsite: DYKYQPrrrKsVKNG SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): R178‑me, SOX9 (mouse): R178‑me, SOX9 (rat): R178‑me, SOX9 (chicken): R178‑me
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE CARM1 (mouse) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell cycle regulation, cell growth, induced, transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNB1 (human) Disrupts co-immunoprecipitation
Comments:  promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis

R179-me - SOX9 (mouse)
Modsite: YKYQPrrrKsVKNGQ SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): R179‑me, SOX9 (mouse): R179‑me, SOX9 (rat): R179‑me, SOX9 (chicken): R179‑me
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE CARM1 (mouse) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell cycle regulation, cell growth, induced, transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNB1 (human) Disrupts co-immunoprecipitation
Comments:  promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis