Curated Information
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Home > Curated Information Page > Cst Curation Set #290
Goss V (2004) CST Curation Set: 290; Year: 2004; Biosample/Treatment: cell line, MEC1/-; Disease: chronic lymphocytic leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y518-p - Ack (human)
Modsite: GGVKkPtyDPVSEDQ SwissProt Entrez-Gene
Orthologous residues
Ack (human): Y518‑p, Ack iso3 (human): Y596‑p, Ack (mouse): Y533‑p, Ack iso2 (mouse): Y518‑p, Ack (rat): Y518‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y674-p - CBL (human)
Modsite: sssANAIysLAARPL SwissProt Entrez-Gene
Orthologous residues
CBL (human): Y674‑p, CBL (mouse): Y672‑p, CBL (rat): Y673‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y15-p - CDK1 (human)
Modsite: EkIGEGtyGVVykGR SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): Y15‑p, CDK1 iso2 (human): Y15‑p, CDK1 (mouse): Y15‑p, CDK1 (rat): Y15‑p, CDK1 (chicken): Y15‑p, CDK1 (fruit fly): Y15‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y15-p - CDK2 (human)
Modsite: EkIGEGtyGVVykAR SwissProt Entrez-Gene
Orthologous residues
CDK2 (human): Y15‑p, CDK2 iso2 (human): Y15‑p, CDK2 (mouse): Y15‑p, CDK2 (rat): Y15‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y15-p - CDK3 (human)
Modsite: EkIGEGtyGVVyKAK SwissProt Entrez-Gene
Orthologous residues
CDK3 (human): Y15‑p, CDK3 (mouse): Y15‑p, CDK3 (cow): Y15‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y473-p - CENTD1 (human)
Modsite: SSQAISPyACFyGAS SwissProt Entrez-Gene
Orthologous residues
CENTD1 (human): Y473‑p, CENTD1 (mouse): Y471‑p, CENTD1 (rat): Y468‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y374-p - Diaphanous-1 (human)
Modsite: EQGEEDsyDLkGRLD SwissProt Entrez-Gene
Orthologous residues
Diaphanous‑1 (human): Y374‑p, Diaphanous‑1 iso2 (human): Y365‑p, Diaphanous‑1 (mouse): F365‑p, Diaphanous‑1 (rat): F374‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y315-p - DOK1 (human)
Modsite: CPsQDsLysDPLDST SwissProt Entrez-Gene
Orthologous residues
DOK1 (human): Y315‑p, DOK1 iso3 (human): Y176‑p, DOK1 (mouse): Y314‑p, DOK1 (rat): Y314‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y362-p - DOK1 (human)
Modsite: DPKEDPIyDEPEGLA SwissProt Entrez-Gene
Orthologous residues
DOK1 (human): Y362‑p, DOK1 iso3 (human): Y223‑p, DOK1 (mouse): Y361‑p, DOK1 (rat): Y361‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y377-p - DOK1 (human)
Modsite: PVPPQGLyDLPREPK SwissProt Entrez-Gene
Orthologous residues
DOK1 (human): Y377‑p, DOK1 iso3 (human): Y238‑p, DOK1 (mouse): Y376‑p, DOK1 (rat): Y376‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y409-p - DOK1 (human)
Modsite: yNPAtDDyAVPPPRS SwissProt Entrez-Gene
Orthologous residues
DOK1 (human): Y409‑p, DOK1 iso3 (human): Y270‑p, DOK1 (mouse): Y408‑p, DOK1 (rat): Y408‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y187-p - ERK2 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y279-p - GSK3A (human)
Modsite: RGEPNVsyICsRyyR SwissProt Entrez-Gene
Orthologous residues
GSK3A (human): Y279‑p, GSK3A (mouse): Y279‑p, GSK3A (rat): Y279‑p, GSK3A (cow): Y279‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y216-p - GSK3B (human)
Modsite: RGEPNVsyICsRyyR SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit): Y216‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y374-p - L-plastin (human)
Modsite: IANLFNRyPALHkPE SwissProt Entrez-Gene
Orthologous residues
L‑plastin (human): Y374‑p, L‑plastin (mouse): Y374‑p, L‑plastin (rat): Y374‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y136-p - LAB (human)
Modsite: EDDDANsyENVLICK SwissProt Entrez-Gene
Orthologous residues
LAB (human): Y136‑p, LAB (mouse): Y139‑p, LAB (rat): Y140‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y193-p - LAB (human)
Modsite: EDEEsEDyQNsAsIH SwissProt Entrez-Gene
Orthologous residues
LAB (human): Y193‑p, LAB (mouse): Y160‑p, LAB (rat): Y161‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y192-p - Lck (human)
Modsite: NLDNGGFyIsPRItF SwissProt Entrez-Gene
Orthologous residues
Lck (human): Y192‑p, Lck iso3 (human): Y192‑p, Lck (mouse): Y192‑p, Lck (rat): Y192‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y505-p - Lck (human)
Modsite: FTAtEGQyQPQP___ SwissProt Entrez-Gene
Orthologous residues
Lck (human): Y505‑p, Lck iso3 (human): Y535‑p, Lck (mouse): Y505‑p, Lck (rat): Y505‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y317-p - PAG (human)
Modsite: EEEIsAMyssVNKPG SwissProt Entrez-Gene
Orthologous residues
PAG (human): Y317‑p, PAG (mouse): Y314‑p, PAG (rat): Y314‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y639-p - PDE10A (human)
Modsite: RKQLEEMyQTGSLNL SwissProt Entrez-Gene
Orthologous residues
PDE10A (human): Y639‑p, PDE10A iso2 (human): Y649‑p, PDE10A (mouse): Y643‑p, PDE10A iso3 (mouse): Y649‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y649-p - PDE10A iso2 (human)
Modsite: RKQLEEMyQTGSLNL SwissProt Entrez-Gene
Orthologous residues
PDE10A (human): Y639‑p, PDE10A iso2 (human): Y649‑p, PDE10A (mouse): Y643‑p, PDE10A iso3 (mouse): Y649‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y849-p - PRP4 (human)
Modsite: ADNDItPyLVsRFyR SwissProt Entrez-Gene
Orthologous residues
PRP4 (human): Y849‑p, PRP4 (mouse): Y849‑p, PRP4 (rat): Y849‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y579-p - Pyk2 (human)
Modsite: RyIEDEDyykAsVTR SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y579‑p, Pyk2 iso2 (human): Y579‑p, Pyk2 (mouse): Y579‑p, Pyk2 (rat): Y579‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

Y580-p - Pyk2 (human)
Modsite: yIEDEDyykAsVTRL SwissProt Entrez-Gene
Orthologous residues
Pyk2 (human): Y580‑p, Pyk2 iso2 (human): Y580‑p, Pyk2 (mouse): Y580‑p, Pyk2 (rat): Y580‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  leukemia, chronic lymphocytic leukemia
Relevant cell lines - cell types - tissues:  MEC1 (B lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human