Curated Information
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Home > Curated Information Page > PubMed Id: 17919121
Zou T, et al. (2008) Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1. Biochem J 409, 389-98 17919121
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K22-ac - KPNA2 (human)
Modsite: HRFKNkGkDsTEMRR SwissProt Entrez-Gene
Orthologous residues
KPNA2 (human): K22‑ac, KPNA2 (mouse): K22‑ac, KPNA2 (rat): K22‑ac
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  regulates subcellular localization of HuR

S105-p - KPNA2 (human)
Modsite: QAARkLLsREkQPPI SwissProt Entrez-Gene
Orthologous residues
KPNA2 (human): S105‑p, KPNA2 (mouse): S105‑p, KPNA2 (rat): S105‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (human) activation of upstream enzyme, pharmacological activator of upstream enzyme, transfection of wild-type enzyme, inhibition of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase polyamines
antimycin_A increase
decrease ornithine decarboxylase
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  regulates subcellular localization of HuR