Curated Information
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Home > Curated Information Page > PubMed Id: 19570885
Vallon V, et al. (2009) Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol 297, F704-12 19570885
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T53-p - NCCT (mouse)
Modsite: GstLyMRtFGYNtID SwissProt Entrez-Gene
Orthologous residues
NCCT (human): T55‑p, NCCT iso2 (human): T55‑p, NCCT iso3 (human): T55‑p, NCCT (mouse): T53‑p, NCCT (rat): T53‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
low-salt diet increase
high-salt diet decrease
low-potassium diet increase
high-potassium diet decrease

T58-p - NCCT (mouse)
Modsite: MRtFGYNtIDVVPAY SwissProt Entrez-Gene
Orthologous residues
NCCT (human): T60‑p, NCCT iso2 (human): T60‑p, NCCT iso3 (human): T60‑p, NCCT (mouse): T58‑p, NCCT (rat): T58‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
low-salt diet increase
high-salt diet decrease
low-potassium diet increase
high-potassium diet decrease

S71-p - NCCT (mouse)
Modsite: AYEHYANsALPGEPR SwissProt Entrez-Gene
Orthologous residues
NCCT (human): S73‑p, NCCT iso2 (human): S73‑p, NCCT iso3 (human): S73‑p, NCCT (mouse): S71‑p, NCCT (rat): S71‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
low-salt diet increase
high-salt diet decrease
low-potassium diet increase
high-potassium diet decrease