Curated Information
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Home > Curated Information Page > PubMed Id: 19622790
Nayak TK, et al. (2009) Inhibition of human two-pore domain K+ channel TREK1 by local anesthetic lidocaine: negative cooperativity and half-of-sites saturation kinetics. Mol Pharmacol 76, 903-17 19622790
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S348-p - TREK-1 (human)
Modsite: KETRRRLsVEIYDKF SwissProt Entrez-Gene
Orthologous residues
TREK‑1 (human): S348‑p, TREK‑1 iso2 (human): S333‑p, TREK‑1 iso3 (human): S344‑p, TREK‑1 (mouse): S348‑p
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  activity, inhibited
Comments:  lidocaine- treated cells