Curated Information
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Home > Curated Information Page > PubMed Id: 19471022
Golebiowski F, et al. (2009) System-wide changes to SUMO modifications in response to heat shock. Sci Signal 2, ra24 19471022
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K1517-sm - KI-67 (human)
Modsite: QskRsLRkVDVEEEF SwissProt Entrez-Gene
Orthologous residues
KI‑67 (human): K1517‑sm, KI‑67 iso2 (human): K1157‑sm, KI‑67 (mouse): K1491‑sm, KI‑67 (rat): K1501‑sm, KI‑67 iso4 (rat): K1455‑sm
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  bone cancer
Relevant cell lines - cell types - tissues:  U2OS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock increase

K524-sm - RANGAP1 (human)
Modsite: LVHMGLLkSEDkVkA SwissProt Entrez-Gene
Orthologous residues
RANGAP1 (human): K524‑sm, RANGAP1 (mouse): K526‑sm, RANGAP1 (rat): K523‑sm, RANGAP1 (cow): K522‑sm
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  bone cancer
Relevant cell lines - cell types - tissues:  U2OS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock increase

K294-sm - SAFB1 (human)
Modsite: DsLLAVVkREPAEQP SwissProt Entrez-Gene
Orthologous residues
SAFB1 (human): K294‑sm, SAFB1 iso2 (human): K225‑sm, SAFB1 iso3 (human): K294‑sm, SAFB1 (mouse): K316‑sm, SAFB1 (rat): K316‑sm
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  bone cancer
Relevant cell lines - cell types - tissues:  U2OS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock increase

K11-sm - SUMO2 (human)
Modsite: EkPkEGVktENNDHI SwissProt Entrez-Gene
Orthologous residues
SUMO2 (human): K11‑sm, SUMO2 iso2 (human): K11‑sm, SUMO2 (mouse): K11‑sm, SUMO2 (rat): K11‑sm
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  bone cancer
Relevant cell lines - cell types - tissues:  U2OS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock increase

K11-sm - SUMO3 (human)
Modsite: EkPkEGVktENDHIN SwissProt Entrez-Gene
Orthologous residues
SUMO3 (human): K11‑sm, SUMO3 (mouse): K11‑sm, SUMO3 (rat): K11‑sm
Characterization
Methods used to characterize site in vivo mass spectrometry
Disease tissue studied:  bone cancer
Relevant cell lines - cell types - tissues:  U2OS (bone cell)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock increase