Dupre-Crochet S, et al. (2007) Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts. Mol Cell Biol 27, 3804-16 17353278

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S844-p - CDH1 (human) ▲

Modsite: GsGsEAAsLSsLNsS SwissProt Entrez-Gene Orthologous residues CDH1 (human): S844‑p, CDH1 (mouse): S846‑p, CDH1 (rat): S848‑p Characterization Methods used to characterize site in vivo:  microscopy-colocalization with upstream kinase, mutation of modification site Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  L929 (fibroblast), MCF-7 (breast cell), MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog, human, mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK1D (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CK1A (human) co-immunoprecipitation, microscopy-colocalization, modification site within consensus motif KINASE CK1E (human) co-immunoprecipitation, modification site within consensus motif Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Effect of modification (process):  cell adhesion, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CTNNB1 (human) Disrupts co-immunoprecipitation

S847-p - CDH1 (human) ▲
Modsite: sEAAsLSsLNsSEsD SwissProt Entrez-Gene Orthologous residues CDH1 (human): S847‑p, CDH1 (mouse): S849‑p, CDH1 (rat): S851‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A1 (human) Comments:  S847, S850, and/or S853

S850-p - CDH1 (human) ▲
Modsite: AsLSsLNsSEsDKDQ SwissProt Entrez-Gene Orthologous residues CDH1 (human): S850‑p, CDH1 (mouse): S852‑p, CDH1 (rat): S854‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A1 (human) Comments:  S847, S850, and/or S853

S853-p - CDH1 (human) ▲
Modsite: SsLNsSEsDKDQDYD SwissProt Entrez-Gene Orthologous residues CDH1 (human): S853‑p, CDH1 (mouse): S855‑p, CDH1 (rat): S857‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK2A1 (human) Comments:  S847, S850, and/or S853