Curated Information
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Home > Curated Information Page > PubMed Id: 17400554
Nguyen C, et al. (2007) Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. J Biol Chem 282, 16511-20 17400554
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S6-p - PPP1R1A (rat)
Modsite: __MEPDNsPRKIQFT SwissProt Entrez-Gene
Orthologous residues
PPP1R1A (human): S6‑p, PPP1R1A (mouse): S6‑p, PPP1R1A (rat): S6‑p, PPP1R1A (rabbit): S6‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, cerebral cortex', 'brain, hippocampus', 'brain, striatum', PC-12 (chromaffin)
Cellular systems studied:  cell lines, tissue
Species studied:  mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK5 (mouse) pharmacological inhibitor of upstream enzyme
PHOSPHATASE PPP1CA (mouse) pharmacological inhibitor of upstream enzyme
PHOSPHATASE PPP2R5A (mouse) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
seliciclib decrease
butyrolactone decrease
U0126 no change compared to control
indolinone_A decrease
indolinone_B no change compared to control
fostriecin increase
neurabin increase
ciclosporin no change compared to control
okadaic_acid increase
NMDA decrease
colforsin increase

T35-p - PPP1R1A (rat)
Modsite: QIRRRRPtPATLVLT SwissProt Entrez-Gene
Orthologous residues
PPP1R1A (human): T35‑p, PPP1R1A (mouse): T35‑p, PPP1R1A (rat): T35‑p, PPP1R1A (rabbit): T35‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, striatum'
Cellular systems studied:  tissue
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA decrease

S67-p - PPP1R1A (rat)
Modsite: LKSTLsMsPRQRKKM SwissProt Entrez-Gene
Orthologous residues
PPP1R1A (human): S67‑p, PPP1R1A (mouse): S67‑p, PPP1R1A (rat): S67‑p, PPP1R1A (rabbit): S67‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'muscle, skeletal', kidney
Cellular systems studied:  tissue
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (human)