Morrison BH, et al. (2007) Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. J Biol Chem 282, 15349-56 17379600

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S473-p - Akt1 (human) ▲

Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene Orthologous residues Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNF increase

S347-p - IHPK2 (human) ▲

Modsite: RPEVVLDsDAEDLED SwissProt Entrez-Gene Orthologous residues IHPK2 (human): S347‑p, IHPK2 iso4 (human): ‑, IHPK2 (mouse): S369‑p, IHPK2 (rat): S346‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  apoptosis, induced, cell growth, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Induces EMSA TRAF2 (human) Induces molecular association, regulation in vitro, co-immunoprecipitation Comments:  induces NFkB-DNA binding

S359-p - IHPK2 (human) ▲

Modsite: LEDLsEEsADESAGA SwissProt Entrez-Gene Orthologous residues IHPK2 (human): S359‑p, IHPK2 iso4 (human): ‑, IHPK2 (mouse): S381‑p, IHPK2 (rat): S358‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  apoptosis, induced, cell growth, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays TRAF2 (human) Induces molecular association, regulation in vitro, co-immunoprecipitation Induces EMSA Comments:  induces NFkB-DNA binding

Y701-p - STAT1 (human) ▲

Modsite: DGPkGtGyIktELIs SwissProt Entrez-Gene Orthologous residues STAT1 (human): Y701‑p, STAT1 iso2 (human): Y701‑p, STAT1 (mouse): Y701‑p, STAT1 (rat): Y701‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes IFN-beta increase siRNA increase siRNA IHKP2

T184-p - TAK1 (human) ▲

Modsite: GtACDIQtHMtNNKG SwissProt Entrez-Gene Orthologous residues TAK1 (human): T184‑p, TAK1 iso2 (human): T184‑p, TAK1 (mouse): T184‑p, TAK1 iso3 (mouse): T184‑p, TAK1 (rat): T184‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNF increase

T187-p - TAK1 (human) ▲

Modsite: CDIQtHMtNNKGsAA SwissProt Entrez-Gene Orthologous residues TAK1 (human): T187‑p, TAK1 iso2 (human): T187‑p, TAK1 (mouse): T187‑p, TAK1 iso3 (mouse): T187‑p, TAK1 (rat): T187‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  ovarian cancer Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TNF increase