Curated Information
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Home > Curated Information Page > PubMed Id: 17379600
Morrison BH, et al. (2007) Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. J Biol Chem 282, 15349-56 17379600
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S473-p - Akt1 (human)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  ovarian cancer
Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TNF increase

S347-p - IHPK2 (human)
Modsite: RPEVVLDsDAEDLED SwissProt Entrez-Gene
Orthologous residues
IHPK2 (human): S347‑p, IHPK2 iso4 (human): , IHPK2 (mouse): S369‑p, IHPK2 (rat): S346‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Disease tissue studied:  ovarian cancer
Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian)
Cellular systems studied:  cell lines
Species studied:  human

S359-p - IHPK2 (human)
Modsite: LEDLsEEsADESAGA SwissProt Entrez-Gene
Orthologous residues
IHPK2 (human): S359‑p, IHPK2 iso4 (human): , IHPK2 (mouse): S381‑p, IHPK2 (rat): S358‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Disease tissue studied:  ovarian cancer
Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian)
Cellular systems studied:  cell lines
Species studied:  human

Y701-p - STAT1 (human)
Modsite: DGPkGtGyIktELIs SwissProt Entrez-Gene
Orthologous residues
STAT1 (human): Y701‑p, STAT1 iso2 (human): Y701‑p, STAT1 (mouse): Y701‑p, STAT1 (rat): Y701‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  ovarian cancer
Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IFN-beta increase
siRNA increase siRNA IHKP2

T184-p - TAK1 (human)
Modsite: GtACDIQtHMtNNKG SwissProt Entrez-Gene
Orthologous residues
TAK1 (human): T184‑p, TAK1 (mouse): T184‑p, TAK1 iso3 (mouse): T184‑p, TAK1 (rat): T184‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  ovarian cancer
Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TNF increase

T187-p - TAK1 (human)
Modsite: CDIQtHMtNNKGsAA SwissProt Entrez-Gene
Orthologous residues
TAK1 (human): T187‑p, TAK1 (mouse): T187‑p, TAK1 iso3 (mouse): T187‑p, TAK1 (rat): T187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  ovarian cancer
Relevant cell lines - cell types - tissues:  OVCAR3 (ovarian)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TNF increase