Bertholomey ML, et al. (2018) Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol. Proteomes 6 30322021

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S365-p - GJA1 (rat) ▲

Modsite: IVDQRPSsRASSRAS SwissProt Entrez-Gene Orthologous residues GJA1 (human): S365‑p, GJA1 (mouse): S365‑p, GJA1 (rat): S365‑p, GJA1 (rabbit): S365‑p, GJA1 (pig): S365‑p, GJA1 (hamster): S365‑p, GJA1 (cow): S366‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes corticosterone increase sucrose, corticosterone increase ethanol, corticosterone increase

S368-p - GJA1 (rat) ▲

Modsite: QRPSSRAsSRASSRP SwissProt Entrez-Gene Orthologous residues GJA1 (human): S368‑p, GJA1 (mouse): S368‑p, GJA1 (rat): S368‑p, GJA1 (rabbit): S368‑p, GJA1 (pig): S368‑p, GJA1 (hamster): S368‑p, GJA1 (cow): S369‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes corticosterone increase sucrose, corticosterone increase ethanol, corticosterone increase

S369-p - GJA1 (rat) ▲

Modsite: RPSSRASsRASSRPR SwissProt Entrez-Gene Orthologous residues GJA1 (human): S369‑p, GJA1 (mouse): S369‑p, GJA1 (rat): S369‑p, GJA1 (rabbit): S369‑p, GJA1 (pig): S369‑p, GJA1 (hamster): S369‑p, GJA1 (cow): S370‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes corticosterone increase sucrose, corticosterone increase ethanol, corticosterone increase

S1014-p - mGluR5 (rat) ▲

Modsite: PAAARPRsPSPISTL SwissProt Entrez-Gene Orthologous residues mGluR5 (human): S1018‑p, mGluR5 (mouse): S1014‑p, mGluR5 (rat): S1014‑p, mGluR5 iso2 (rat): S982‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes sucrose, corticosterone increase ethanol, corticosterone increase

S1016-p - mGluR5 (rat) ▲

Modsite: AARPRSPsPISTLSH SwissProt Entrez-Gene Orthologous residues mGluR5 (human): S1020‑p, mGluR5 (mouse): S1016‑p, mGluR5 (rat): S1016‑p, mGluR5 iso2 (rat): S984‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes sucrose, corticosterone increase ethanol, corticosterone increase

S43-p - PPP1R1A (rat) ▲

Modsite: PATLVLTsDQSSPEV SwissProt Entrez-Gene Orthologous residues PPP1R1A (human): S43‑p, PPP1R1A (mouse): S43‑p, PPP1R1A (rat): S43‑p, PPP1R1A (rabbit): S43‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes sucrose, corticosterone increase ethanol, corticosterone increase

S46-p - PPP1R1A (rat) ▲

Modsite: LVLTSDQsSPEVDED SwissProt Entrez-Gene Orthologous residues PPP1R1A (human): S46‑p, PPP1R1A (mouse): S46‑p, PPP1R1A (rat): S46‑p, PPP1R1A (rabbit): S46‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes sucrose, corticosterone increase ethanol, corticosterone increase

S47-p - PPP1R1A (rat) ▲

Modsite: VLTSDQSsPEVDEDR SwissProt Entrez-Gene Orthologous residues PPP1R1A (human): S47‑p, PPP1R1A (mouse): S47‑p, PPP1R1A (rat): S47‑p, PPP1R1A (rabbit): S47‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes sucrose, corticosterone increase ethanol, corticosterone increase

S121-p - PPP1R2 (rat) ▲

Modsite: FRTREQEsSGEEDND SwissProt Entrez-Gene Orthologous residues PPP1R2 (human): S121‑p, PPP1R2 (mouse): S122‑p, PPP1R2 (rat): S121‑p, PPP1R2 (rabbit): S121‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes sucrose, corticosterone decrease ethanol, corticosterone increase

S122-p - PPP1R2 (rat) ▲

Modsite: RTREQESsGEEDNDL SwissProt Entrez-Gene Orthologous residues PPP1R2 (human): S122‑p, PPP1R2 (mouse): S123‑p, PPP1R2 (rat): S122‑p, PPP1R2 (rabbit): S122‑p Characterization Methods used to characterize site in vivo:  mass spectrometry Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes sucrose, corticosterone decrease ethanol, corticosterone increase