Curated Information
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Home > Curated Information Page > PubMed Id: 19565571
Wu H, Symes K, Seldin DC, Dominguez I (2009) Threonine 393 of beta-catenin regulates interaction with Axin. J Cell Biochem 108, 52-63 19565571
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S33-p - CTNNB1 (human)
Modsite: QQQsyLDsGIHsGAT SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p, CTNNB1 (rabbit): S33‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTNNB1 (human) decrease decreased by CTNNB1 T393 phosphorylation

S37-p - CTNNB1 (human)
Modsite: yLDsGIHsGATtTAP SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p, CTNNB1 (rabbit): S37‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTNNB1 (human) decrease decreased by CTNNB1 T393 phosphorylation

T41-p - CTNNB1 (human)
Modsite: GIHsGATtTAPsLsG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p, CTNNB1 (rabbit): T41‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTNNB1 (human) decrease decreased by CTNNB1 T393 phosphorylation

T393-p - CTNNB1 (human)
Modsite: RNLSDAAtkQEGMEG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p, CTNNB1 (rabbit): T393‑p
Downstream Regulation
Effect of modification (function):  activity, induced, molecular association, regulation, phosphorylation, protein stabilization
Effect of modification (process):  transcription, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
axin 1 (human) Disrupts in vitro
Comments:  decreases phosphorylation of CTNNB1 S33/S37/T41