Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 30295850
Li Z, et al. (2018) RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation. Nucleic Acids Res 30295850
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S295-p - DDX1 (rat)
Modsite: KALIVEPsRELAEQT SwissProt Entrez-Gene
Orthologous residues
DDX1 (human): S295‑p, DDX1 (mouse): S295‑p, DDX1 (rat): S295‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, western blotting
Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
Relevant cell lines - cell types - tissues:  INS-1 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
palmitate increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Induces translation, inhibited pull-down assay
Comments:  insulin translation inhibited

S481-p - DDX1 (rat)
Modsite: NTRPGANsPEMWSEA SwissProt Entrez-Gene
Orthologous residues
DDX1 (human): S481‑p, DDX1 (mouse): S481‑p, DDX1 (rat): S481‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
palmitate increase