Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 17217339
Pacquelet S, et al. (2007) Cross-talk between IRAK-4 and the NADPH oxidase. Biochem J 403, 451-61 17217339
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

T133-p - p47phox (human)
Modsite: KLPTDNQtKKPEtyL SwissProt Entrez-Gene
Orthologous residues
p47phox (human): T133‑p, p47phox (mouse): A133‑p, p47phox (rat): V133‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  neutrophil
Cellular systems studied:  primary cultured cells
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IRAK4 (human) activation of upstream enzyme, co-immunoprecipitation, microscopy-colocalization
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase

T138-p - p47phox (human)
Modsite: NQtKKPEtyLMPKDG SwissProt Entrez-Gene
Orthologous residues
p47phox (human): T138‑p, p47phox (mouse): T138‑p, p47phox (rat): T138‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)

T153-p - p47phox (human)
Modsite: KSTATDItGPIILQT SwissProt Entrez-Gene
Orthologous residues
p47phox (human): T153‑p, p47phox (mouse): T153‑p, p47phox (rat): T153‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)

Y279-p - p47phox (human)
Modsite: TGYFPSMyLQKsGQD SwissProt Entrez-Gene
Orthologous residues
p47phox (human): Y279‑p, p47phox (mouse): Y279‑p, p47phox (rat): Y279‑p

S288-p - p47phox (human)
Modsite: QKsGQDVsQAQRQIK SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S288‑p, p47phox (mouse): T288‑p, p47phox (rat): T288‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  neutrophil
Cellular systems studied:  primary cultured cells
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IRAK4 (human) activation of upstream enzyme, co-immunoprecipitation, microscopy-colocalization
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase

S320-p - p47phox (human)
Modsite: QRsRKRLsQDAYRRN SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S320‑p, p47phox (mouse): S321‑p, p47phox (rat): S321‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  neutrophil
Cellular systems studied:  primary cultured cells
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IRAK4 (human) activation of upstream enzyme, co-immunoprecipitation, microscopy-colocalization
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase

S345-p - p47phox (human)
Modsite: QARPGPQsPGsPLEE SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S345‑p, p47phox (mouse): S346‑p, p47phox (rat): S346‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  neutrophil
Cellular systems studied:  primary cultured cells
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IRAK4 (human) activation of upstream enzyme, co-immunoprecipitation, microscopy-colocalization
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase

S348-p - p47phox (human)
Modsite: PGPQsPGsPLEEERQ SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S348‑p, p47phox (mouse): G349‑p, p47phox (rat): S349‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)

T356-p - p47phox (human)
Modsite: PLEEERQtQRsKPQP SwissProt Entrez-Gene
Orthologous residues
p47phox (human): T356‑p, p47phox (mouse): T356‑p, p47phox (rat): T355‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  neutrophil
Cellular systems studied:  primary cultured cells
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IRAK4 (human) activation of upstream enzyme, co-immunoprecipitation, microscopy-colocalization
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase

S359-p - p47phox (human)
Modsite: EERQtQRsKPQPAVP SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S359‑p, p47phox (mouse): V359‑p, p47phox (rat): A358‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)

S370-p - p47phox (human)
Modsite: PAVPPRPsADLILNR SwissProt Entrez-Gene
Orthologous residues
p47phox (human): S370‑p, p47phox (mouse): S370‑p, p47phox (rat): S369‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)