Faiola F, et al. (2007) Max is acetylated by p300 at several nuclear localization residues. Biochem J 403, 397-407 17217336

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K40-ac - MAX (human) ▲
Modsite: RKRRDHIkDsFHsLR SwissProt Entrez-Gene Orthologous residues MAX (human): K40‑ac, MAX iso2 (human): K31‑ac, MAX (mouse): K40‑ac, MAX iso2 (mouse): K31‑ac, MAX (rat): K40‑ac, MAX iso2 (rat): K31‑ac Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro) Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE p300 (human)

K66-ac - MAX (human) ▲

Modsite: SRAQILDkAtEyIQy SwissProt Entrez-Gene Orthologous residues MAX (human): K66‑ac, MAX iso2 (human): K57‑ac, MAX (mouse): K66‑ac, MAX iso2 (mouse): K57‑ac, MAX (rat): K66‑ac, MAX iso2 (rat): K57‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mass spectrometry (in vitro), mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE p300 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes ACETYLTRANSFERASE p300 (human) transfection of wild-type enzyme Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Effect of modification (process):  transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Disrupts B-Myc (mouse) Induces co-immunoprecipitation

K153-ac - MAX (human) ▲

Modsite: PEEPQSRkkLRMEAS SwissProt Entrez-Gene Orthologous residues MAX (human): K153‑ac, MAX iso2 (human): K144‑ac, MAX (mouse): K153‑ac, MAX iso2 (mouse): K144‑ac, MAX (rat): K153‑ac, MAX iso2 (rat): K144‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mass spectrometry (in vitro), mutation of modification site Relevant cell lines - cell types - tissues:  COS7 (fibroblast), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE p300 (human) Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Effect of modification (process):  transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Disrupts B-Myc (mouse) Induces co-immunoprecipitation

K154-ac - MAX (human) ▲

Modsite: EEPQSRkkLRMEAS_ SwissProt Entrez-Gene Orthologous residues MAX (human): K154‑ac, MAX iso2 (human): K145‑ac, MAX (mouse): K154‑ac, MAX iso2 (mouse): K145‑ac, MAX (rat): K154‑ac, MAX iso2 (rat): K145‑ac Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mass spectrometry (in vitro), mutation of modification site Relevant cell lines - cell types - tissues:  COS7 (fibroblast), HeLa (cervical) Cellular systems studied:  cell lines Species studied:  green monkey, human Enzymes shown to modify site in vitro:  Type Enzyme ACETYLTRANSFERASE p300 (human) Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Effect of modification (process):  transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Disrupts B-Myc (mouse) Induces co-immunoprecipitation