Curated Information
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Home > Curated Information Page > PubMed Id: 17145764
Pollok-Kopp B, H├╝ttenrauch F, Rethorn S, Oppermann M (2007) Dynamics of protein kinase C-mediated phosphorylation of the complement C5a receptor on serine 334. J Biol Chem 282, 4345-53 17145764
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S327-p - C5aR (human)
Modsite: RNVLtEEsVVREsKs SwissProt Entrez-Gene
Orthologous residues
C5aR (human): S327‑p, C5aR (mouse): S328‑p, C5aR iso3 (mouse): S328‑p, C5aR (rat): S329‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered
Comments:  induces translocation of beta-arrestin into the plasma membrane

S332-p - C5aR (human)
Modsite: EEsVVREsKsFTRsT SwissProt Entrez-Gene
Orthologous residues
C5aR (human): S332‑p, C5aR (mouse): S333‑p, C5aR iso3 (mouse): S333‑p, C5aR (rat): S334‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered
Comments:  induces translocation of beta-arrestin into the plasma membrane

S334-p - C5aR (human)
Modsite: sVVREsKsFTRsTVD SwissProt Entrez-Gene
Orthologous residues
C5aR (human): S334‑p, C5aR (mouse): T335‑p, C5aR iso3 (mouse): T335‑p, C5aR (rat): S336‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil), U-937 (myeloid)
Cellular systems studied:  cell lines
Species studied:  human, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
KINASE PKCB iso2 (human)
KINASE PKCB (human)
KINASE PKCD (human)
KINASE PKCG (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB iso2 (human) pharmacological inhibitor of upstream enzyme
KINASE PKCB (human) pharmacological inhibitor of upstream enzyme
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered
Comments:  induces translocation of beta-arrestin to the plasma membrane

S338-p - C5aR (human)
Modsite: EsKsFTRsTVDTMAQ SwissProt Entrez-Gene
Orthologous residues
C5aR (human): S338‑p, C5aR (mouse): S339‑p, C5aR iso3 (mouse): S339‑p, C5aR (rat): S340‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered
Comments:  induces translocation of beta-arrestin into the plasma membrane