Curated Information
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Home > Curated Information Page > PubMed Id: 11030732
Baillie GS, MacKenzie SJ, McPhee I, Houslay MD (2000) Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases. Br J Pharmacol 131, 811-9 11030732
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S659-p - PDE4B (human)
Modsite: YQSMIPQsPSPPLDE SwissProt Entrez-Gene
Orthologous residues
PDE4B (human): S659‑p, PDE4B iso2 (human): S487‑p, PDE4B iso3 (human): S644‑p, PDE4B (mouse): S644‑p, PDE4B (rat): S659‑p, PDE4B iso1 (rat): S644‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited
Comments:  increases levels of cAMP

S487-p - PDE4B iso2 (human)
Modsite: YQSMIPQsPSPPLDE SwissProt Entrez-Gene
Orthologous residues
PDE4B (human): S659‑p, PDE4B iso2 (human): S487‑p, PDE4B iso3 (human): S644‑p, PDE4B (mouse): S644‑p, PDE4B (rat): S659‑p, PDE4B iso1 (rat): S644‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Comments:  decreases levels of cAMP

S535-p - PDE4C iso2 (human)
Modsite: YQSKIPRsPSDLTNP SwissProt Entrez-Gene
Orthologous residues
PDE4C (human): S641‑p, PDE4C iso2 (human): S535‑p, PDE4C (mouse): S642‑p, PDE4C (rat): S507‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited

S579-p - PDE4D iso2 (human)
Modsite: YQSTIPQsPSPAPDD SwissProt Entrez-Gene
Orthologous residues
PDE4D (human): S715‑p, PDE4D iso2 (human): S579‑p, PDE4D iso4 (human): S490‑p, PDE4D iso5 (human): S413‑p, PDE4D iso6 (human): S651‑p, PDE4D iso7 (human): , PDE4D iso9 (human): S593‑p, PDE4D iso10 (human): S585‑p, PDE4D (mouse): S654‑p, PDE4D iso2 (mouse): S585‑p, PDE4D iso3 (mouse): S491‑p, PDE4D iso4 (mouse): , PDE4D iso9 (mouse): , PDE4D (rat): S710‑p, PDE4D iso6 (rat): S585‑p, PDE4D iso8 (rat): S652‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)