Curated Information
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Home > Curated Information Page > PubMed Id: 17087658
Sheth P, et al. (2007) Acetaldehyde dissociates the PTP1B-E-cadherin-beta-catenin complex in Caco-2 cell monolayers by a phosphorylation-dependent mechanism. Biochem J 402, 291-300 17087658
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y331-p - CTNNB1 (human)
Modsite: LVNIMRTytyEkLLW SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y331‑p, CTNNB1 (mouse): Y331‑p, CTNNB1 (rat): Y331‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Caco-2 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
acetaldehyde increase

Y333-p - CTNNB1 (human)
Modsite: NIMRTytyEkLLWTT SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y333‑p, CTNNB1 (mouse): Y333‑p, CTNNB1 (rat): Y333‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Caco-2 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
acetaldehyde increase

Y489-p - CTNNB1 (human)
Modsite: QNAVRLHyGLPVVVk SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y489‑p, CTNNB1 (mouse): Y489‑p, CTNNB1 (rat): Y489‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Caco-2 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human

Y654-p - CTNNB1 (human)
Modsite: RNEGVAtyAAAVLFR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Caco-2 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
acetaldehyde increase

Y670-p - CTNNB1 (human)
Modsite: SEDKPQDykKRLsVE SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y670‑p, CTNNB1 (mouse): Y670‑p, CTNNB1 (rat): Y670‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Caco-2 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
acetaldehyde increase

Y716-p - CTNNB1 (human)
Modsite: YRQDDPsyRsFHsGG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y716‑p, CTNNB1 (mouse): Y716‑p, CTNNB1 (rat): Y716‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Caco-2 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human