To KK, et al. (2006) The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. EMBO J 25, 4784-94 17024177

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T324-p - HIF2A (human) ▲

Modsite: VWLETQGtVIYNPRN SwissProt Entrez-Gene Orthologous residues HIF2A (human): T324‑p, HIF2A (mouse): T324‑p, HIF2A (rat): T324‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  bone cancer Relevant cell lines - cell types - tissues:  U2OS (bone cell) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PDK1 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  apoptosis, induced, transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SP1 (human) Disrupts molecular association, regulation co-immunoprecipitation